It is an carbazole based cannabinoid that is the carbazole analogue of JWH-018 and so is perfect for researchers in countries where other cannabinoids are controlled. Like chemicals such as THJ-018 and AB-PINACA, it has relatively low in-vitro CB1/CB2 activity but is still interesting for researchers who like to study that type of synthetic cannabinoid.
Scientists can conduct experiments to determine the basic data on the material, such as melting points, and solublities etc. and see how it compares and contrasts with the data from similar chemicals.
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Buy JWH-018 online (1-pentyl-3-(1-naphthoyl)indole) or AM-678is an analgesic chemical from the naphthoylindole family that acts as a full agonist at both the CB1 and CB2 cannabinoid receptors, with some selectivity for CB2. It produces effects in animals similar to those of tetrahydrocannbinol (THC), a cannabinoid naturally present in cannabis, leading to its use in synthetic cannabis products such as “legal cannabis herbal incense blends” which in some countries are sold legally as “incense”, labeled “not for human
Buy JWH-018 online is a full agonist of both the CB1 and CB2 cannabinoid receptors, with a reported binding affinity of 9.00 ± 5.00 nM at CB1 and 2.94 ± 2.65 nM at CB2. JWH-018 has an EC50 of 102 nM for human CB1 receptors, and 133 nM for human CB2 receptors. JWH-018 produces bradycardia and hypothermia in rats at doses of 0.3–3 mg/kg, suggesting potent cannabinoid-like activity
Replacing the α-methyl with a cyclopropyl dramatically reduces affinity for the noradrenaline transporter and 5-HT2A receptor targets, while retaining high serotonin transporter affinity and markedly increasing affinity for the dopamine transporter (and as such, it is one of the few selective SDRIs or serotonin-dopamine reuptake inhibitors). This change causes Buy UWA-101 online to lack cytotoxicity and MDMA-like behavioral effects in animals, but while retaining similar or slightly improved anti-Parkinsonian effectiveness when compared to MDMA.